Neuro Note on Alzheimer’s

TED talk by Lisa Genova

I chose to do my neuro note on Alzheimer’s because I wanted to learn more about it this neurological disease. Alzheimer’s occurs when amyloid betta accumulates in the brains synapses forming amyloid plaque. Once the plaque reaches a tipping point is when someone starts to experience the symptoms of Alzheimer’s.
 Before I listened to the TED talk I thought that if a person had the Alzheimer’s gene they inevitably got the disease.  This is not 100% true. Having the gene is one small component of getting Alzheimer’s and even then, you are still not guaranteed to get this neurological disease. Lisa mentioned a few ways that a person can decreases their chance of getting Alzheimer’s, these include; getting adequate sleep, aerobic exercise, and decent cardiovascular health (diabetes, smoking, obesity, hypertension). However, Lisa’s main solution to preventing Alzheimer’s has to do with neuroplasticity.
In class I learned that neuroplasticity is the brains ability to create new neural connections throughout life. We create new pathways by learning something new or doing mentally stimulating activities. This is a preventative measure for Alzheimer’s because the brain is able to make the new connections, diverting from the synapse that is destroyed. In the TED talk Lisa mentioned a study done on a group of nuns. Many of the nuns had countless synapses that were destroyed by plaque, but they did not show any symptoms of Alzheimer’s. The researchers strongly agree that this is due to cognitive reserve, which means they had more functional synapses. In summary, we can be resilient to Alzheimer’s through recruitment of undamaged pathways. A person can create new pathways by, learning a new language, meeting new people, reading a book, and several other mentally stimulating activities. I thought this TED talk was extremely informative, and I will absolutely recommend it to my mom and grandmother. As occupational therapist, we can encourage our clients to do mentally stimulating activities, not only to prevent Alzheimer’s, but to improve their overall brain function.

Reference:

Genova, L. (2017, April). What you can do to prevent Alzheimer's. Retrieved April 05, 2018, from https://www.ted.com/talks/lisa_genova_what_you_can_do_to_prevent_alzheimer_s#t-18260



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